Saget, best known for his role as Danny Tanner on Full House, was found unresponsive in a room at the Ritz-Carlton Orlando in Florida.
The Orange Country Sherriff’s Office said there appeared to be “no signs of foul play or drug use” in Saget’s death.
The cause of death will be determined by the medical examiner, the Sheriff’s office added.
Saget was in the midst of a tour at the time of his death that was set to take him to locations in New York, Canada and several other locations in the coming months.
According to tour dates pinned to his Twitter account, he performed on Saturday night at Ponte Vedra Beach, Florida.
He tweeted after the show, “Loved tonight’s show @PV_ConcertHall in Jacksonville. Appreciative audience. Thanks again to @RealTimWilkins for opening. I had no idea I did a 2 hr set tonight. I’m happily addicted again to this s—.”
Saget, though known on the stage and among his friends for his raunchy humour, first became known to audiences on family-friendly programming.
He starred as the widowed father of three girls on Full House and then as host of the America’s Funniest Home Videos clip show.
Full House co-star John Stamos said he was “broken” and “gutted” by the news of Saget’s death.
As Saget recalled the Jake Tapper in a July 2021 interview, the track of his career was unexpected.
“Full House was an accident,” he said.
“I got fired on CBS and was asked to be in Full House.”
The sitcom, which starred Candace Cameron Bure, Jodie Sweetin and twins Mary Kate and Ashley Olsen in one role, ran for eight seasons.
It lived on in syndication with strong enough nostalgia surrounding it that Netflix picked up a spin-off in 2016, Fuller House, starring Bure but featuring frequent appearances from original stars, including Saget, Dave Coulier and Stamos.
It ran for five seasons, concluding in 2020.
“I’m close with all the kids. It doesn’t happen a lot in the world where you stay close with all the people,” Saget told Tapper.
“We’re an unusual cast in that way that I have been able to remain close with everybody, because I don’t take eight years of my life lightly and then the other five or six years, six seasons.”
Following his first round of sitcom fame, Saget worked steadily in film and television roles but became known to a new generation of sitcom fans on How I Met Your Mother, acting as narrator and the voice of future Ted Mosby.
That show ran until 2014.
Throughout the years, Saget remained a fixture in stand-up comedy, releasing multiple specials over the years and taking his show on the road.
According to his website, Saget often hosted comedy events to raise money for the Scleroderma Research Foundation, for which he served on the board of directors.
He lost his sister to the chronic disease in 1994, his website said.
In 2020, he launched a podcast, titled Bob Saget’s Here For You, an interview show where he welcomed guests like Tiffany Haddish, Jason Sudeikis, Whoopi Goldberg and Norman Lear.